Cytochrome P450 and UGT Reaction Phenotyping Studies
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Reaction phenotyping experiments can identify the number and type of enzymes responsible for drug clearance. Liver microsomes coupled with enzyme selective chemical or antibody inhibitors, as well as a panel of cDNA-expressed enzymes provide a robust approach to determining the number and identity of enzymes involved in the metabolism of a test compound.
Metabolism can be measured by loss of parent compound and/or formation of metabolites.
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Services
BD GentestSM Contract Research Services offer multiple protocols to meet both discovery and development needs. HPLC analysis with absorbance, fluorescence, radiometric, or mass spectrometric detection is available.
FDA-sponsored guidance documents
BD protocols are consistent with experimental approaches in the literature and current FDA-sponsored guidance documents.
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Consult the ADME Experts
Call 888.334.5229, ext. 2246, to discuss your contract needs. Customers outside the U.S. may reach us at 781.935.5115, ext. 2246. |
