ADME/Tox Source

Permeability and Transport Studies

Transporters are essential in the delivery and excretory processes of drugs and their metabolites. Drugs that inhibit membrane transporters can alter the absorption, disposition, and elimination of co-administered drugs that are substrates of these transport proteins and can affect bioavailability or cause drug-drug interactions.

Services

BD Gentest^SM Contract Research Services offers a range of services to evaluate drug-transporter interactions using in vitro models expressing human and animal transporters from the ABC and SLC superfamilies.

ABC Transporter Services

• P-gp/MRP/BCRP/BSEP Membranes and Vesicles »
• MDR1 LLC-Pk₁ and Caco-2 Cell Models »

SLC Transporter Services

• Transportocytes - Xenopus laevis oocytes preinjected with OAT, OATP, OCT, NTCP, and PEPT transporter cRNA »

Consult the ADME Experts

Call 888.334.5229, ext. 2246, to discuss your contract needs. Customers outside the U.S. may reach us at 781.935.5115, ext. 2246.