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Major drug-binding proteins such as lipoproteins, albumin, and alpha1-glycoprotein in plasma play an essential role in a drugís availability to cross membrane barriers and interact with targets. Drugs that compete for binding sites within these proteins may produce drug-drug interactions. In order to reduce the risk of failure of a new chemical entity (NCE), and ensure a therapeutic effect for patients, it is necessary to conduct protein binding assays.
BD Biosciences offers the BD Gentest™ Serum Binding System, for use in the bound versus free protein separation procedure. Protein binding Contract Research Services include an automated plasma protein binding service using equilibrium dialysis, solubility, and aggregation testing.
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Accurate Results
Results consistent with literature values and demonstrating minimal variation.
Automation Friendly
Compatible with automated microplate and liquid handling systems.
Rapid Equilibrium Dialysis
Specialized Spectra/PorÆ 2 dialysis membrane, and top chamber design with one third the volume of the lower chamber facilitate rapid equilibrium dialysis.
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Protein Binding
Contract Research Services
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